Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.
Urolithin A (UA), a compound made by gut bacteria from foods like pomegranates and berries, has been shown to boost cell health, improve energy production in cells, and reduce harmful inflammation. Recent studies suggest UA could help protect against aging and age-related issues in muscles, brain, and joints, with some clinical trials showing benefits for older adults.
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its impact on aging and disease been explored. UA enhances cellular health by increasing mitophagy and mitochondrial function and reducing detrimental inflammation. Several preclinical studies show how UA protects against aging and age-related conditions affecting muscle, brain, joints, and other organs. In humans, benefits of UA supplementation in the muscle are supported by recent clinical trials in elderly people. Here, we review the state of the art of UA's biology and its translational potential as a nutritional intervention in humans.
Key Points
- UA comes from gut bacteria breaking down foods like pomegranates, berries, and nuts.
- UA helps cells clean up damaged parts and work better, which may slow aging.
- Early studies show UA could improve muscle health in older people.
- UA might also support brain and joint health by reducing inflammation.
- Eating foods rich in UA precursors could be a simple way to promote healthy aging.
Our Take
The research on this topic is promising and shows significant potential for improving health outcomes. Based on the evidence, implementing these findings through lifestyle changes and targeted supplementation could provide notable benefits.
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View on AmazonSource: PubMed